Vitamin-D
Vitamin-D3 25-OH
| REF | Volume |
|---|---|
| N/A | N/A |
Product description:
Vitamin D is well known for its classic role in the maintenance of bone mineral density. In
conjunction with parathyroid hormone (PTH), Vitamin D plays a critical role in calcium
homeostasis. However, in recent years, Vitamin D has been receiving increased attention due to
the resurgence of Vitamin D deficiency and rickets in developed countries. High prevalence of
vitamin D deficiency is also seen throughout India. Many studies on the incidence of Vitamin D
deficiency (i.e., 25-(OH) D< 20 ng/mL) in community-based Indian studies on apparently healthy
controls reported a prevalence ranging from 50% to 94% for a last one decade. Numerous
scientific and medical researchers have provided strong evidence supporting the correlations
between Vitamin D insufficiency and increased risks of developing non-skeletal pathologies
including cancer, heart diseases, stroke, diabetes, hypertension, autoimmune diseases,
infectious diseases, and aging.
In the blood, Vitamin D exists as a protein bound form, specifically with a Vitamin D
binding protein. Clinically, Vitamin D levels in the blood get reported as the total 25-OH
Vitamin D, which is the sum of 25-(OH) D3 and 25-(OH) D2.Traditionally, analytical methods
for Vitamin D determination have been measured by competitive binding, high-performance
liquid chromatography (HPLC), and radioimmunoassay (RIA) methods. However, despite their
functionality, these methods (HPLC, RIA, and LC-MS/MS) tend to be labour intensive and
technically difficult. They are often not fully automated, have low throughputs, and
LC-MS/MS method is not commonly available in most clinical laboratories.
The innovative Q-Line Platinum Vitamin D assay is a 2-reagent, direct particle enhanced
immunoturbidimetric assay for use on general clinical chemistry analyzers, without need of
any cumbersome sample preparatory steps or special instrument.
